Prostacyclin deficiency in haemolytic-uraemic syndrome.
نویسندگان
چکیده
منابع مشابه
Inhibitor of prostacyclin production in sporadic haemolytic uraemic syndrome.
Prostacyclin (PGI2) production was diminished when rat aortic rings were incubated with plasma from 5 of 6 patients with the sporadic form of haemolytic uraemic syndrome but was normal in the presence of plasma from 7 patients with the epidemic form of haemolytic uraemic syndrome or from patients with other renal diseases. The reduced PGI2 production was caused by an unstable inhibitor, extract...
متن کاملProstacyclin concentrations in haemolytic uraemic syndrome after acute shigellosis.
The role of prostacyclin in the pathogenesis of haemolytic uraemic syndrome was evaluated in 11 children with acute shigellosis. Plasma concentrations of 6-keto prostaglandin, F1 alpha, a stable metabolite of prostacyclin, were measured by radioimmunoassay during acute illness, early convalescence, and after clinical recovery. Its concentration was low during acute illness in each patient, retu...
متن کاملAtypical haemolytic uraemic syndrome.
The haemolytic uraemic syndrome (HUS) is characterized by the triad of thrombocytopenia, microangiopathic haemolytic anaemia and acute renal failure. HUS may be classified as either diarrhoeal-associated or non-diarrhoeal/atypical (aHUS). aHUS has recently been shown to be a disease of complement dysregulation, with 50% of cases involving the complement regulatory genes, factor H (CFH), membran...
متن کاملHaemolytic uraemic syndrome
Haemolytic uraemic syndrome and the related disorder thrombotic thrombocytopenic purpura have recently been the subject of much interest and research.' A wide variety of phenomena have been observed and several pathogenetic mechanisms have been proposed, matched by a correspondingly diverse array of promising but unsubstantiated methods of treatment. Consideration of the heterogeneity of the cl...
متن کاملHaemolytic uraemic syndrome
Haemolytic uraemic syndrome and the related disorder thrombotic thrombocytopenic purpura have recently been the subject of much interest and research.' A wide variety of phenomena have been observed and several pathogenetic mechanisms have been proposed, matched by a correspondingly diverse array of promising but unsubstantiated methods of treatment. Consideration of the heterogeneity of the cl...
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ژورنال
عنوان ژورنال: BMJ
سال: 1980
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.281.6235.271